Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3894154 | 0.69 | — | — | |
| SCHEMBL2352229 | 0.66 | CALM1 (0.52) | CALM1TAAR1BCL2BCL2L1LMNA | |
| SCHEMBL9566501 | 0.63 | CALM1 (0.61) | CALM1TAAR1BCL2BCL2L1LMNA | |
| SCHEMBL1923108 | 0.61 | CALM1 (0.58) | CALM1TAAR1BCL2BCL2L1LMNA | |
| Fluoride Ion SCHEMBL1131310 | 0.60 | — | — | |
| Diphenylmethane SCHEMBL29700351 | 0.60 | CALM1 (0.86) | CALM1TAAR1BCL2BCL2L1LMNA | |
| Diphenylmethane SCHEMBL27450549 | 0.60 | CALM1 (0.86) | CALM1TAAR1BCL2BCL2L1LMNA | |
| SCHEMBL6253349 | 0.59 | CALM1 (0.42) | CALM1TAAR1BCL2BCL2L1LMNA | |
| SCHEMBL6251956 | 0.59 | CALM1 (0.42) | CALM1TAAR1BCL2BCL2L1LMNA | |
| Diphenylmethane SCHEMBL3792579 | 0.59 | CALM1 (1.00) | CALM1BCL2BCL2L1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1241188-B1 | COMPONENT OF CATALYST FOR OLEFIN POLYMERIZATION | JAPAN POLYCHEM CORP (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-6677411-B2 | AS CATALYST SUPPORT AN ION-EXCHANGE LAYERED SILICATE HAVING A SPECIFIC PORE SIZE DISTRIBUTION CURVE | JAPAN POLYCHEM CORPORATION (JP) | 2004-01-13 | — | — | US | disclosed |
| US-20030027950-A1 | Component of catalyst for olefin polymerization | JAPAN POLYCHEM CORPORATION (JP) | 2003-02-06 | — | — | US | disclosed |
| EP-1241188-A1 | COMPONENT OF CATALYST FOR OLEFIN POLYMERIZATION | Japan Polychem Corporation (JP) | 2002-09-18 | — | — | EP | disclosed |