Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 16/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.61 |
| ▸ | KLK1 | P06870 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.43 |
| ▸ | F7 | P08709 | 3/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | F12 | P00748 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1281452 | 0.89 | F11 (0.63) | F11PRSS1PRSS2PRSS3KLK1 | |
| SCHEMBL1281446 | 0.89 | F11 (0.63) | F11PRSS1PRSS2PRSS3KLK1 | |
| SCHEMBL392698 | 0.85 | KDM4E (0.47) | F11KLKB1 | |
| SCHEMBL5517905 | 0.85 | KDM4E (0.47) | F11KLKB1 | |
| SCHEMBL393746 | 0.82 | F11 (0.55) | F11PRSS1PRSS2PRSS3KLK1 | |
| SCHEMBL393745 | 0.82 | F11 (0.55) | F11PRSS1PRSS2PRSS3KLK1 | |
| SCHEMBL392202 | 0.82 | ROCK2 (0.41) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL394811 | 0.76 | TACR3 (0.38) | F11PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL392725 | 0.76 | F11 (1.00) | F11PRSS1PRSS2PRSS3KLK1 | |
| SCHEMBL1281251 | 0.76 | F11 (1.00) | F11PRSS1PRSS2PRSS3KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-04-12 | — | — | US | disclosed |
| US-8101778-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088758-A1 | FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | F12, F11, F5 | F11 2/4885PRSS1 19/4885PRSS2 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.