Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3890946 | 1.00 | MEN1 (0.39) | MEN1KMT2APARP1USP2MAPT | |
| SCHEMBL4633743 | 0.99 | MEN1 (0.40) | MEN1KMT2APARP1USP2MAPT | |
| SCHEMBL5711637 | 0.99 | MEN1 (0.40) | MEN1KMT2APARP1USP2MAPT | |
| Bromide SCHEMBL4532718 | 0.87 | MEN1 (0.41) | MEN1KMT2AUSP2MAPTPOLB | |
| Bromide SCHEMBL4534732 | 0.87 | MEN1 (0.41) | MEN1KMT2AUSP2MAPTPOLB | |
| SCHEMBL9010771 | 0.81 | MAPT (0.49) | MEN1KMT2APARP1USP2MAPT | |
| Bromide SCHEMBL4535352 | 0.78 | KMT2A (0.42) | MEN1KMT2AUSP2MAPTCYP1A2 | |
| Bromide SCHEMBL4535340 | 0.78 | KMT2A (0.42) | MEN1KMT2AUSP2MAPTCYP1A2 | |
| SCHEMBL3905741 | 0.77 | CISD1 (0.46) | MEN1KMT2APARP1USP2MAPT | |
| SCHEMBL3890952 | 0.77 | CISD1 (0.46) | MEN1KMT2APARP1USP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553336-B2 | Brightening direct dyes for keratin fibers and colorants containing these compounds | WELLA AG (DE) | 2009-06-30 | — | — | US | claimed |
| US-7544215-B2 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | WELLA AG (DE) | 2009-06-09 | — | — | US | claimed |
| EP-1729723-B1 | NEUTRAL AND CATIONIC NAPHTHALENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS FOR DYEING KERATIN FIBERS | WELLA AG (DE) | 2008-06-04 | — | — | EP | claimed |
| US-20070151046-A1 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | Wella GmbH (DE) | 2007-07-05 | — | — | US | claimed |
| US-20070119000-A1 | Brightening direct dyes for keratin fibers and colorants containing these compounds | WELLA AG (DE) | 2007-05-31 | — | — | US | claimed |
| US-7553336-B2 | Brightening direct dyes for keratin fibers and colorants containing these compounds | WELLA AG (DE) | 2009-06-30 | — | — | US | disclosed |
| US-7544215-B2 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | WELLA AG (DE) | 2009-06-09 | — | — | US | disclosed |
| US-20070151046-A1 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | Wella GmbH (DE) | 2007-07-05 | — | — | US | disclosed |
| US-20070119000-A1 | Brightening direct dyes for keratin fibers and colorants containing these compounds | WELLA AG (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070119000-A1 | Brightening direct dyes for keratin fibers and colorants containing these compounds | KRT18, MKI67, TUBB1 | ACHE 3525/4885MEN1 1644/4885KMT2A 1329/4885 |
| US-20070151046-A1 | Neutral and cationic naphthalene and colorants for keratin fibers containing these compounds | KRT18, NUP205, KPNA1 | ACHE 4227/4885MEN1 2181/4885KMT2A 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.