Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3888189 | 0.78 | HTR7 (0.39) | HTR2CHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL13866925 | 0.75 | CNR2 (0.39) | HTR2CHTR2BALDH1A1RAB9ATSHR | |
| SCHEMBL13866932 | 0.75 | CNR2 (0.39) | HTR2CHTR2BALDH1A1RAB9ATSHR | |
| SCHEMBL13867220 | 0.73 | PDE4A (0.36) | HTR2CHTR2BMEN1KMT2AALDH1A1 | |
| SCHEMBL13866935 | 0.72 | EPHX2 (0.34) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3885212 | 0.70 | HPGD (0.43) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL18096451 | 0.67 | PTGER4 (0.47) | MEN1KMT2AALDH1A1LMNARAB9A | |
| SCHEMBL13867221 | 0.65 | HTR7 (0.37) | MEN1KMT2AALDH1A1TSHRHDAC10 | |
| SCHEMBL22125717 | 0.65 | POLB (0.49) | MEN1KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL20569226 | 0.64 | ADORA1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524964-B2 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-28 | — | — | US | disclosed |
| US-7524964-B2 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-28 | — | — | US | disclosed |
| US-7524964-B2 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-28 | — | — | US | disclosed |
| EP-1863479-B1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-10 | — | — | EP | disclosed |
| EP-1863479-B1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-10 | — | — | EP | disclosed |
| US-20080085899-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | LIOTTA FINA | 2008-04-10 | — | — | US | disclosed |
| US-20080085899-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | LIOTTA FINA | 2008-04-10 | — | — | US | disclosed |
| US-20080085899-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | LIOTTA FINA | 2008-04-10 | — | — | US | disclosed |
| EP-1863479-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS CROSS REFERENCE TO RELATED APPLICATIONS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107561-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-10-12 | — | — | WO | disclosed |
| US-20060223798-A1 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223798-A1 | Tetrahydrothiopyrano pyrazole cannabinoid modulators | CNR1, CNR2, GPR18 | HTR2C 19/4885HTR2B 189/4885MEN1 4352/4885 |
| US-20080085899-A1 | TETRAHYDROTHIOPYRANO PYRAZOLE CANNABINOID MODULATORS | CNR1, CNR2, GPR18 | HTR2C 19/4885HTR2B 189/4885MEN1 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.