Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188354 | 0.83 | DRD2 (0.60) | DRD2DRD3ADRA1AADRA1BADRA1D | |
| SCHEMBL27651774 | 0.78 | DRD2 (0.43) | DRD2DRD3ADRA2CALDH1A1L3MBTL1 | |
| SCHEMBL14621895 | 0.78 | DRD2 (0.67) | DRD2DRD3ADRA1AADRA1BADRA1D | |
| SCHEMBL4117842 | 0.76 | ADRA2C (0.39) | DRD2DRD3ADRA2CALDH1A1HTR1A | |
| SCHEMBL8513730 | 0.74 | ADRA2C (0.37) | DRD2DRD3ADRA2CALDH1A1HTR1A | |
| SCHEMBL188362 | 0.74 | ADRA2C (0.42) | DRD2DRD3ADRA2CALDH1A1HTR1A | |
| SCHEMBL4113163 | 0.74 | DRD2 (0.51) | DRD2DRD3ADRA2CALDH1A1HTR1A | |
| SCHEMBL285241 | 0.73 | DRD2 (0.60) | DRD2DRD3ADRA1AADRA1BADRA1D | |
| SCHEMBL3582056 | 0.73 | ADRA2C (0.39) | DRD2DRD3ADRA2CALDH1A1HTR1A | |
| SCHEMBL3400411 | 0.73 | DRD2 (0.59) | DRD2DRD3ADRA1AADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-A1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007119046-A1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |