Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.81 |
| ▸ | APEX1 | P27695 | 1/20 | 0.78 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.67 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.66 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893598 | 1.00 | STAT3 (0.81) | STAT3APEX1PTPN22MAPTPTPN12 | |
| SCHEMBL16492645 | 0.90 | PTPN22 (0.75) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL3893475 | 0.90 | PTPN22 (0.72) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL3893480 | 0.90 | PTPN22 (0.72) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL13056366 | 0.90 | MAPT (0.79) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL13056328 | 0.89 | HIF1AN (0.81) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL3893594 | 0.89 | MEN1 (0.72) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL16496688 | 0.89 | STAT3 (1.00) | STAT3APEX1PTPN22PTPN12MAP3K5 | |
| SCHEMBL8594082 | 0.89 | MAP3K5 (0.78) | STAT3APEX1PTPN22MAPTMAP3K5 | |
| SCHEMBL8594085 | 0.89 | MAP3K5 (0.78) | STAT3APEX1PTPN22MAPTMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | claimed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2004043955-A1 | RHODANINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RIGEL PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | UBQLN1, UBQLN2, UBE2G2 | STAT3 1781/4885APEX1 1572/4885PTPN22 3961/4885 |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RBX1, ITCH, UBQLN1 | STAT3 3636/4885APEX1 888/4885PTPN22 3667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.