SCHEMBL3893595

SCHEMBL3893595

[C-]#[N+]Cc1ccc(OC(F)(F)F)cc1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 4/20 0.40
SCN5A Q14524 2/20 0.39
CHRM5 P08912 1/20 0.38
FFAR4 Q5NUL3 4/20 0.36
CYP3A4 P08684 1/20 0.36
KCNH2 Q12809 1/20 0.36
CACNA1C Q13936 1/20 0.36
MAOB P27338 1/20 0.36
AOC3 Q16853 1/20 0.36
PDE2A O00408 1/20 0.35
PPARG P37231 1/20 0.35
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
CYP1A2 P05177 2/20 0.34
HRH4 Q9H3N8 1/20 0.34
FFAR1 O14842 1/20 0.34
KIF11 P52732 1/20 0.34
SLC6A4 P31645 2/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A3 Q01959 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12630661 0.81 APLNR (0.41) MAOB
SCHEMBL14143900 0.81 CHRM5 (0.43) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL13568401 0.79 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL20817904 0.79 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL966621 0.79 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL13137672 0.79 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL12135071 0.79 FFAR4 (0.42) GPR3SCN5ACHRM5FFAR4CYP3A4
Hydrochloric Acid SCHEMBL2203322 0.78 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL16961512 0.78 GPR3 (0.41) GPR3SCN5ACHRM5FFAR4CYP3A4
SCHEMBL13579085 0.77 HTR2A (0.46) GPR3SCN5ACHRM5FFAR4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009145719-A1 ISOINDOLINE DERIVATIVES COMPRISING A CYANO GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145718-A1 ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed