Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | GLA | P06280 | 2/20 | 0.71 |
| ▸ | ACHE | P22303 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL2261509 | 1.00 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL2261516 | 1.00 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL31162550 | 1.00 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL3893629 | 1.00 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL30253833 | 0.87 | ALDH1A1 (0.94) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL1772714 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL29352289 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL3045498 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL8339 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE | |
| Acridine SCHEMBL4972293 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699282-A4 | COMPOSITIONS AND METHODS FOR DETECTING REVERSE TRANSCIPTASE IN A SAMPLE | QUEST DIAGNOSTICS INVEST INC (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1699282-A2 | COMPOSITIONS AND METHODS FOR DETECTING REVERSE TRANSCIPTASE IN A SAMPLE | Quest Diagnostics Investments Incorporated (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005065350-A2 | COMPOSITIONS AND METHODS FOR DETECTING REVERSE TRANSCIPTASE IN A SAMPLE | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED (US) | 2005-07-21 | — | — | WO | disclosed |
| US-20050147965-A1 | Compositions and methods for detecting reverse transcriptase in a sample | QUEST DIAGNOSTICS INVESTMENTS INCORPORATED | 2005-07-07 | — | — | US | disclosed |