Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | FDPS | P14324 | 10/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732151 | 0.95 | TSHR (0.44) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL28626292 | 0.93 | TSHR (0.42) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL7735780 | 0.93 | TSHR (0.42) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL28211171 | 0.90 | TSHR (0.39) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL28171004 | 0.87 | TSHR (0.37) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL1714213 | 0.87 | TSHR (0.42) | TSHRFDPSGGPS1EPHX1ADH1B | |
| SCHEMBL11170814 | 0.86 | TSHR (0.38) | TSHRFDPSEPHX1ADH1BADH1C | |
| SCHEMBL9578391 | 0.85 | FDPS (0.39) | FDPSGGPS1 | |
| SCHEMBL20873210 | 0.85 | FDPS (0.39) | FDPSGGPS1 | |
| SCHEMBL28422225 | 0.85 | TSHR (0.41) | TSHRFDPSGGPS1EPHX1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517895-B2 | Synthetic diazonamides | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-04-14 | — | — | US | disclosed |
| US-20060089397-A1 | Synthetic diazonamides | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-04-27 | — | — | US | disclosed |
| US-7022720-B2 | Synthetic diazonamides as novel anti-mitotic agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-04-04 | — | — | US | disclosed |
| US-20030100589-A1 | Synthetic diazonamides as novel anti-mitotic agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089397-A1 | Synthetic diazonamides | BUB1B, BUB1, CDK15 | TSHR 3210/4885FDPS 1169/4885GGPS1 3066/4885 |
| US-20030100589-A1 | Synthetic diazonamides as novel anti-mitotic agents | BUB1B, BUB1, BUB3 | TSHR 3852/4885FDPS 1682/4885GGPS1 3107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.