Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.35 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214228 | 1.00 | TP53 (0.39) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL41028 | 0.97 | TP53 (0.41) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL4102518 | 0.94 | TP53 (0.39) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL7600624 | 0.94 | TP53 (0.39) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL29156768 | 0.83 | CYP3A4 (0.48) | TP53POLBKMT2APKMPTPN7 | |
| SCHEMBL28129894 | 0.83 | TP53 (0.32) | TP53 | |
| SCHEMBL4418220 | 0.83 | CYP3A4 (0.55) | TP53POLBKMT2APKMPTPN7 | |
| SCHEMBL1579329 | 0.79 | TDP1 (0.50) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL619505 | 0.79 | TDP1 (0.50) | TP53POLBKMT2AALDH1A1MEN1 | |
| SCHEMBL1784193 | 0.77 | TP53 (0.39) | TP53POLBKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628030-B1 | 2,3,4,5-TETRAHYDRO-1H --3-BENZAZEPINES HAVING ANTI-PSYCHOTIC ACTIVITY, AND SYNTHESIS OF $g(a)-SUBSTITUTED-ARYLACETAMIDES | SCHERING CORP (US) | 2002-12-11 | — | — | EP | claimed |
| EP-0791594-A2 | 2-Aryl-5,11-dihydro-6H-dipyrido 3,2-b:2',3'-e 1,4 diazepines and their use for the preparation of pharmaceutical compositions for the treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1997-08-27 | — | — | EP | claimed |
| US-5530125-A | REACTING ARYLACETAMIDE WITH STRONG BASE IN INERT APROTIC SOLVENT, THEN WITH SPECIFIED REACTANT IN PRESENCE OF TRANSITION METAL CATALYST TO ADD ALPHA-SUBSTITUENT,REDUCING TO AMINE | SCHERING CORPORTION (US) | 1996-06-25 | — | — | US | claimed |
| US-7547710-B2 | Fused heterocyclic compounds as peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-16 | — | — | US | disclosed |
| EP-1527049-B8 | FUSED HETEROCYCLIC COMPOUNDS AS PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2008-10-29 | — | — | EP | disclosed |
| EP-1527049-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PEPTIDASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2008-07-16 | — | — | EP | disclosed |
| EP-1355886-B1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1515970-B1 | ALKYNYLPURINE COMPOUNDS AND PRODUCTION METHODS THEREOF | SUMITOMO CHEMICAL CO (JP) | 2006-10-18 | — | — | EP | disclosed |
| US-20060135530-A1 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| US-20060100429-A1 | Alkynylpurine compounds and production methods thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-05-11 | — | — | US | disclosed |
| US-7034039-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-25 | — | — | US | disclosed |
| WO-1993011128-A1 | AMINOALKYLPYRROLIDINYLTHIOCARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-10 | — | — | WO | disclosed |
| EP-0545290-A1 | Aminoalkylpyrrolidinylthiocarbapenem derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |
| EP-0544307-A1 | Alkylaminoakylpyrrolidinylthiocarbapenem derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-02 | — | — | EP | disclosed |
| WO-1993001192-A1 | 2-(2-SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-01-21 | — | — | WO | disclosed |
| EP-0522504-A1 | 2-(2-substituted pyrrolidinylthio)-carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1993-01-13 | — | — | EP | disclosed |
| US-5095013-A | Antibiotics | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1992-03-10 | — | — | US | disclosed |
| WO-1991014687-A1 | 2-(SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-10-03 | — | — | WO | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |
| EP-0411664-A2 | 2-(2-Vinylpyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-02-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135530-A1 | Fused heterocyclic compounds | NR4A3, DPP3, INSR | TP53 1774/4885POLB 3753/4885KMT2A 1923/4885 |
| US-20060100429-A1 | Alkynylpurine compounds and production methods thereof | TPMT, IMPDH1, IMPDH2 | TP53 2587/4885POLB 1160/4885KMT2A 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.