SCHEMBL3897052

SCHEMBL3897052

O=CC(Cc1ccccc1)CN(O)C=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.41
CYP1A2 P05177 1/20 0.40
HDAC2 Q92769 4/20 0.40
HDAC8 Q9BY41 4/20 0.40
HDAC6 Q9UBN7 3/20 0.40
HDAC1 Q13547 2/20 0.40
BMP1 P13497 1/20 0.39
MMP12 P39900 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
SLC1A3 P43003 1/20 0.39
SLC1A2 P43004 1/20 0.39
SLC1A1 P43005 1/20 0.39
ALPI P09923 1/20 0.38
PKM P14618 1/20 0.38
PTGS1 P23219 1/20 0.38
XIAP P98170 1/20 0.38
SLC7A5 Q01650 1/20 0.38
CPA3 P15088 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5188987 0.83 HDAC1 (0.44) CYP1A2HDAC2HDAC8HDAC6HDAC1
SCHEMBL16449742 0.79 TAAR1 (0.46) EPHX1CYP1A2MEN1KMT2ATAAR1
SCHEMBL3699986 0.79 EPHX1 (0.53) EPHX1SLC1A3SLC1A2SLC1A1ALPI
SCHEMBL3771287 0.79 EPHX1 (0.53) EPHX1SLC1A3SLC1A2SLC1A1ALPI
SCHEMBL7266299 0.79 EPHX1 (0.54) EPHX1CYP1A2MEN1KMT2ATAAR1
SCHEMBL3897048 0.77 EPHX1 (0.39) EPHX1CYP1A2HDAC2HDAC8HDAC6
SCHEMBL14625582 0.77 TRPA1 (0.41) EPHX1CYP1A2HDAC2HDAC8HDAC6
SCHEMBL27309457 0.76 TRPA1 (0.48) EPHX1CYP1A2MEN1KMT2ATAAR1
SCHEMBL3903096 0.76 CYP1A2 (0.49) EPHX1CYP1A2BMP1MMP12SLC1A3
SCHEMBL253605 0.73 EPHX1 (0.44) EPHX1CYP1A2MEN1KMT2ATAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615629-B1 PEPTIDE DEFORMYLASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2009-03-18 EP claimed
EP-1615629-A4 PEPTIDE DEFORMYLASE INHIBITORS CHRISTENSEN SIEGFRIED B IV (US) 2007-02-28 EP disclosed
EP-1615629-A1 PEPTIDE DEFORMYLASE INHIBITORS Christensen, Siegfried B. IV (US) 2006-01-18 EP disclosed
WO-2004098584-A1 PEPTIDE DEFORMYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-11-18 WO disclosed