SCHEMBL3898104

SCHEMBL3898104

CCOC(=O)C(N)Cc1cnn(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
PKM P14618 1/20 0.39
OPRM1 P35372 1/20 0.39
OPRD1 P41143 1/20 0.39
SMN1; SMN2 Q16637 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
ACACB O00763 2/20 0.36
HSD17B10 Q99714 1/20 0.36
GRIA1 P42261 1/20 0.35
GRIA2 P42262 1/20 0.35
GRIA3 P42263 1/20 0.35
GRIA4 P48058 1/20 0.35
GRM2 Q14416 1/20 0.35
TYR P14679 2/20 0.35
TPH1 P17752 2/20 0.35
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3898092 1.00 ALDH1A1 (0.39) ALDH1A1MEN1KMT2APKMOPRM1
SCHEMBL1124429 0.87 MEN1 (0.42) ALDH1A1MEN1KMT2AOPRM1SMN1; SMN2
SCHEMBL21946641 0.87 MEN1 (0.42) ALDH1A1MEN1KMT2AOPRM1SMN1; SMN2
Hydrochloric Acid SCHEMBL20502547 0.85 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AOPRM1SMN1; SMN2
Hydrochloric Acid SCHEMBL31752348 0.85 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AOPRM1SMN1; SMN2
SCHEMBL25353489 0.81 GRIA1 (0.49) PKMHSD17B10GRIA1GRIA2GRIA3
SCHEMBL21946640 0.81 GRIA1 (0.49) PKMHSD17B10GRIA1GRIA2GRIA3
SCHEMBL21879115 0.81 GRIA1 (0.49) PKMHSD17B10GRIA1GRIA2GRIA3
Hydrochloric Acid SCHEMBL31753224 0.76 ALDH1A1 (0.40) ALDH1A1MEN1KMT2AACACBHSD17B10
SCHEMBL17007856 0.76 ALDH1A1 (0.36) ALDH1A1MEN1KMT2APKMOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047425-A4 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2009-04-22 EP disclosed
EP-1040111-B1 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2005-06-22 EP disclosed
EP-1047425-A1 INTEGRIN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2000-11-02 EP disclosed
EP-1040111-A1 INTEGRIN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2000-10-04 EP disclosed
US-6066648-A USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH MERCK & CO., INC. (US) 2000-05-23 US disclosed
WO-1999030709-A1 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1999-06-24 WO disclosed
WO-1999031099-A1 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1999-06-24 WO disclosed