Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dicyclohexylcarbodiimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL3898259 | 0.82 | DPP4 (0.30) | DPP4DPP7ALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL8508859 | 0.80 | EPHX1 (0.60) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL6562189 | 0.76 | EPHX1 (0.50) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL6562192 | 0.76 | EPHX1 (0.50) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL177067 | 0.73 | EPHX1 (0.71) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL5967555 | 0.73 | EPHX1 (0.71) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL5178296 | 0.70 | EPHX1 (0.60) | EPHX1HIF1AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL16824180 | 0.68 | NAPRT (0.50) | ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL9068482 | 0.68 | NAPRT (0.50) | ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL158703 | 0.68 | NAPRT (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501846-B1 | TRICYCLIC MACROLIDE ANTIBACTERIAL COMPOUNDS | ABBOTT LAB (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1501846-A1 | TRICYCLIC MACROLIDE ANTIBACTERIAL COMPOUNDS | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093289-A1 | TRICYCLIC MACROLIDE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2003-11-13 | — | — | WO | disclosed |
| US-5326902-A | Oxyalkyne compounds, pharmaceutical compositions containing them and processes for preparing such compounds and compositions | GRUENENTHAL GMBH (DE) | 1994-07-05 | — | — | US | disclosed |
| CN-1076452-A | 3,4 '-dideoxy mycaminose base tylosin cyclic lactone derivatives and manufacture method thereof | ZAIDAN HOJIN BISEIBUTSU (JP) | 1993-09-22 | — | — | CN | disclosed |
| EP-0035355-B1 | MODIFIED ALUMINIUM HYDRIDES, THEIR PREPARATION AND THEIR USE IN REDUCING ACETYLNAPHTHALENE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-05-09 | — | — | EP | disclosed |
| US-4418218-A | REDUCTION WITH LITHIUM ALUMINUM HYDRIDE AND N-SUBSTITUTED EPHEDRINE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-11-29 | — | — | US | disclosed |
| US-4338255-A | Modified lithium aluminum hydrides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-07-06 | — | — | US | disclosed |
| EP-0035355-A2 | Modified aluminium hydrides, their preparation and their use in reducing acetylnaphthalene derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-09-09 | — | — | EP | disclosed |
| US-4233222-A | Cyclopentylacetic acid derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-11-11 | — | — | US | disclosed |
| US-4210669-A | Prostanoic acid derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-07-01 | — | — | US | disclosed |