Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicyclohexylcarbodiimide SCHEMBL8508859 | 0.88 | EPHX1 (0.60) | EPHX1HIF1AALDH1A1CYP1A2PDK1 | |
| Dicyclohexylcarbodiimide SCHEMBL3970888 | 0.79 | EPHX1 (0.71) | EPHX1HIF1AALDH1A1CYP1A2CES2 | |
| Dicyclohexylcarbodiimide SCHEMBL10525266 | 0.78 | EPHX1 (0.88) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL3173433 | 0.78 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL21986399 | 0.78 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL303 | 0.78 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL15667923 | 0.78 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL11842065 | 0.78 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL27496513 | 0.77 | EPHX1 (0.68) | EPHX1HIF1AALDH1A1CYP1A2CES2 | |
| Dicyclohexylcarbodiimide SCHEMBL28183625 | 0.77 | EPHX1 (0.68) | EPHX1HIF1AALDH1A1CYP1A2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794177-A2 | PROCESS FOR PREPARING 7 -ALKOXYCARBONYL SUBSTITUTED STEROIDS | Pharmacia Corporation (US) | 2007-06-13 | — | — | EP | disclosed |
| CN-1934126-A | Process for the preparation of 9, 11 epoxy steroids | PHARMACIA & UPJOHN CO LLC (US) | 2007-03-21 | — | — | CN | disclosed |
| EP-1730164-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 9,11 EPOXY STEROIDS | Pharmacia & Upjohn Company LLC (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20060264412-A1 | Carbonylation; hydrogenation; for preparation of eplerenone | PHARMACIA CORPORATION (US) | 2006-11-23 | — | — | US | disclosed |
| CN-1839145-A | Steroid spirolactonization | PHARMACIA CORP (US) | 2006-09-27 | — | — | CN | disclosed |
| WO-2004085458-A9 | STEROID SPIROLACTONIZATION | PHARMACIA CORP (US) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006032970-A2 | PROCESS FOR PREPARING 7α-ALKOXYCARBONYL SUBSTITUTED STEROIDS | PHARMACIA CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |
| EP-1606306-A2 | STEROID SPIROLACTONIZATION | Pharmacia Corporation (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20050272927-A1 | Process for the preparation of 9, 11 epoxy steroids | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-12-08 | — | — | US | disclosed |
| WO-2005092913-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 9,11 EPOXY STEROIDS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-10-06 | — | — | WO | disclosed |
| US-20050090663-A1 | Carbonylation; hydrogenation; epoxidation; alkynylation; for preparation of eplerenone | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | US | disclosed |
| WO-2004085458-A2 | STEROID SPIROLACTONIZATION | PHARMACIA CORPORATION (US) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272927-A1 | Process for the preparation of 9, 11 epoxy steroids | CYP11A1, CYP4A11, CYP11B1 | EPHX1 77/4885HIF1A 654/4885ALDH1A1 1511/4885 |
| US-20060264412-A1 | Carbonylation; hydrogenation; for preparation of eplerenone | HSD17B7, HSD17B3, HSD17B2 | EPHX1 486/4885HIF1A 1554/4885ALDH1A1 170/4885 |
| US-20050090663-A1 | Carbonylation; hydrogenation; epoxidation; alkynylation; for preparation of eplerenone | HSD17B7, HSD17B2, HSD17B3 | EPHX1 314/4885HIF1A 1460/4885ALDH1A1 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.