Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27704370 | 0.80 | ADORA2A (0.63) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL3902083 | 0.79 | PABPC1 (0.33) | MAOATHRBMEN1KMT2APOLB | |
| SCHEMBL3900430 | 0.76 | THRB (0.35) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL3898322 | 0.74 | ADORA2A (0.48) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL3902071 | 0.72 | ADORA2A (0.61) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL14612359 | 0.71 | ADORA2A (0.54) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL3897409 | 0.70 | — | — | |
| SCHEMBL3909101 | 0.69 | MAPT (0.64) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL15453235 | 0.68 | PABPC1 (0.50) | ADORA2ACSNK1A1CSNK1DCSNK1G1FGR | |
| SCHEMBL8247267 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383463-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1383463-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | King Pharmaceuticals, Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002083083-A2 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | KING PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |