Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5393745 | 0.89 | TACR1 (0.76) | TACR1SLC6A4 | |
| SCHEMBL3896842 | 0.82 | TACR1 (1.00) | TACR1SLC6A4 | |
| SCHEMBL5374172 | 0.81 | TACR1 (0.88) | TACR1SLC6A4 | |
| SCHEMBL3896705 | 0.80 | TACR1 (0.79) | TACR1SLC6A4 | |
| SCHEMBL5380047 | 0.80 | TACR1 (0.77) | TACR1SLC6A4 | |
| SCHEMBL5390496 | 0.80 | TACR1 (0.88) | TACR1SLC6A4 | |
| SCHEMBL5378383 | 0.80 | TACR1 (1.00) | TACR1SLC6A4 | |
| SCHEMBL5382653 | 0.80 | TACR1 (1.00) | TACR1SLC6A4 | |
| SCHEMBL5382646 | 0.80 | TACR1 (1.00) | TACR1SLC6A4 | |
| SCHEMBL5794588 | 0.80 | TACR1 (1.00) | TACR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494986-B2 | Cycloalkylamine derivatives as NK-1/SSRI antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-02-24 | — | — | US | disclosed |
| US-7494986-B2 | Cycloalkylamine derivatives as NK-1/SSRI antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-02-24 | — | — | US | disclosed |
| US-7494986-B2 | Cycloalkylamine derivatives as NK-1/SSRI antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-02-24 | — | — | US | disclosed |
| US-20060276444-A1 | Porphyrin-polyamine conjugates for cancer therapy | PROGEN PHARMACEUTICALS, INC. | 2006-12-07 | — | — | US | disclosed |
| WO-2006023187-A2 | CYCLOALKYLAMINE DERIVATIVES AS NK-1 /SSRI ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060019992-A1 | Cycloalkylamine derivatives as NK-1/SSRI antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276444-A1 | Porphyrin-polyamine conjugates for cancer therapy | SRM, PAICS, FOLH1 | TACR1 807/4885SLC6A4 1215/4885 |
| US-20060019992-A1 | Cycloalkylamine derivatives as NK-1/SSRI antagonists | SLC6A4, SLC6A2, TPH1 | TACR1 22/4885SLC6A4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.