Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.57 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000440 | 0.85 | NR3C1 (0.59) | NR3C1PGR | |
| SCHEMBL3020936 | 0.84 | NR3C1 (0.57) | NR3C1PGR | |
| SCHEMBL3893244 | 0.83 | NR3C1 (0.56) | NR3C1SMOPGRCYP11B1CYP11B2 | |
| SCHEMBL3010812 | 0.77 | NR3C1 (0.66) | NR3C1PGR | |
| SCHEMBL3892754 | 0.76 | NR3C1 (0.54) | NR3C1SMO | |
| SCHEMBL3901065 | 0.75 | NR3C1 (0.61) | NR3C1SMO | |
| SCHEMBL4275453 | 0.75 | NR3C1 (0.68) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL4281026 | 0.75 | NR3C1 (0.84) | NR3C1PGRCYP11B2 | |
| 2,2,2-Trifluoro-1-(4-Fluorophenyl)-1-(1-(4-Fluorophenyl)-1H-Indazol-5-Yl)Ethanol (Diastereomeric Mix) SCHEMBL4280142 | 0.74 | NR3C1 (1.00) | NR3C1PGRCYP11B1CYP11B2 | |
| SCHEMBL3895042 | 0.74 | NR3C1 (0.58) | NR3C1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102170-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008070507-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-12 | — | — | WO | disclosed |