SCHEMBL3900657

SCHEMBL3900657

Cc1cc(N)c2c(c1)-c1cscc1C2=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.35
MAPT P10636 4/20 0.35
PIM1 P11309 4/20 0.35
ELANE P08246 3/20 0.35
LMNA P02545 2/20 0.35
MEN1 O00255 2/20 0.35
CYP3A4 P08684 2/20 0.35
TSHR P16473 2/20 0.35
MAPK1 P28482 2/20 0.35
KMT2A Q03164 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
ALOX15 P16050 2/20 0.35
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35
MAOA P21397 2/20 0.35
NPC1 O15118 1/20 0.35
PTP4A3 O75365 1/20 0.35
GMNN O75496 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A1 P04798 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3902089 0.80 ALDH1A1 (0.37) ALDH1A1MAPTPIM1MEN1CYP3A4
SCHEMBL3902023 0.78 ALDH1A1 (0.45) ALDH1A1MAPTELANEMEN1CYP3A4
SCHEMBL29191819 0.73 TTR (0.58) ALDH1A1MAPTPIM1ELANEMEN1
SCHEMBL3902622 0.71 MEN1 (0.44) ALDH1A1MAPTPIM1MEN1CYP3A4
SCHEMBL3902705 0.70 ADORA2A (0.60) ALDH1A1MAPTPIM1LMNAMEN1
SCHEMBL21969758 0.70 NSD2 (0.43) ALDH1A1MAPTPIM1ELANELMNA
SCHEMBL3898322 0.69 ADORA2A (0.48) ALDH1A1MAPTPIM1ELANEMEN1
SCHEMBL9672020 0.68 ELANE (0.59) ELANEESR1ESR2MAOAPOLB
SCHEMBL3899297 0.68 ALDH1A1 (0.59) ALDH1A1MAPTPIM1ELANELMNA
SCHEMBL3905717 0.67 THRB (0.39) ALDH1A1MAPTPIM1MEN1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1383463-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE KING PHARMACEUTICALS INC (US) 2009-03-25 EP claimed
EP-1383463-A2 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE King Pharmaceuticals, Inc. (US) 2004-01-28 EP claimed
WO-2002083083-A2 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE KING PHARMACEUTICALS, INC. (US) 2002-10-24 WO claimed
EP-1383463-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE KING PHARMACEUTICALS INC (US) 2009-03-25 EP disclosed
EP-1383463-A2 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE King Pharmaceuticals, Inc. (US) 2004-01-28 EP disclosed
WO-2002083083-A2 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE KING PHARMACEUTICALS, INC. (US) 2002-10-24 WO disclosed