Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904395 | 0.99 | MEN1 (0.66) | MEN1KMT2AEPHX1IL1BP2RX7 | |
| SCHEMBL8007467 | 0.75 | MEN1 (0.62) | MEN1KMT2AIL1BP2RX7TSHR | |
| SCHEMBL3282119 | 0.73 | EPHX2 (0.52) | KMT2AEPHX1EPHX2TP53TSHR | |
| SCHEMBL3911825 | 0.72 | CNR1 (0.50) | LMNA | |
| SCHEMBL3903167 | 0.72 | OPRM1 (0.44) | MEN1KMT2AP2RX7EPHX2CYP1A2 | |
| SCHEMBL3281866 | 0.72 | EPHX2 (0.54) | EPHX1TAAR1EPHX2TP53TSHR | |
| SCHEMBL3916716 | 0.71 | CASR (0.53) | MEN1KMT2ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL3908089 | 0.71 | CASR (0.53) | P2RX7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3907315 | 0.70 | GAA (0.43) | SMN1; SMN2LMNA | |
| SCHEMBL3905862 | 0.70 | CYP2C19 (0.51) | MEN1KMT2AEPHX2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |