Hydrochloric Acid

Hydrochloric Acid

SCHEMBL390312

CC1=Cc2c(-c3ccccc3)cccc2C1[Zr+2]1(C2C(C)=Cc3c(-c4ccccc4)cccc32)CC1.[Cl-].[Cl-]

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
HTR1A P08908 6/20 0.33
HTR7 P34969 6/20 0.33
HTR2B P41595 3/20 0.33
TMEM97 Q5BJF2 3/20 0.33
SIGMAR1 Q99720 2/20 0.33
BRD4 O60885 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
PDK2 Q15119 1/20 0.32
PDK4 Q16654 1/20 0.32
DRD2 P14416 1/20 0.31
DRD1 P21728 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride Ion SCHEMBL7636075 0.97 USP30 (0.33) USP30CHRNB2CHRNA4HTR1AHTR7
Hydrochloric Acid SCHEMBL7192493 0.96 USP30 (0.32) USP30CHRNB2CHRNA4HTR1AHTR7
Hydrochloric Acid SCHEMBL672585 0.94 USP30 (0.32) USP30CHRNB2CHRNA4HTR1AHTR7
Hydrochloric Acid SCHEMBL3267582 0.94 USP30 (0.32) USP30CHRNB2CHRNA4HTR1AHTR7
Hydrochloric Acid SCHEMBL5953240 0.90 NPC1 (0.31)
SCHEMBL3999780 0.90 USP30 (0.32) USP30PDK2PDK4
SCHEMBL4000620 0.86 PDK2 (0.31) USP30PDK2PDK4
Hydrochloric Acid SCHEMBL5953029 0.86 BRD4 (0.32) BRD4
Hydrochloric Acid SCHEMBL6884551 0.85 ABL1 (0.37) HTR1AHTR7DRD2DRD1
Hydrochloric Acid SCHEMBL5274044 0.85 BRD4 (0.34) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2020420-B1 High crystalline polypropylene waxes CLARIANT FINANCE BVI LTD (VG) 2012-10-10 EP claimed
EP-1053263-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2003-10-01 EP claimed
EP-1058694-B1 Catalyst system, method for its production and its use for the polymerisation of olefins BASELL POLYOLEFINE GMBH (DE) 2003-04-09 EP claimed
US-6482902-B1 Catalyst system TARGOR GMBH (DE) 2002-11-19 US claimed
US-6410665-B1 POLYMERIZATION COORDINATION CATALYST FOR ALPHA-OLEFIN BASELL POLYOLEFINE GMBH (DE) 2002-06-25 US claimed
US-6391989-B1 COORDINATION CATALYST ON SUPPORT; POLYMERIZATION OF ALPHA-OLEFINS BASELL POLYPROPYLEN GMBH (DE) 2002-05-21 US claimed
US-6124231-A Supported catalyst system, processes for its preparation, and its use for the polymerization of olefins TARGOR GMBH (DE) 2000-09-26 US claimed
EP-0783022-B2 ETHYLENIC POLYMER COMPOSITION MITSUI CHEMICALS INC (JP) 2016-01-20 EP disclosed
EP-1648946-B1 OLEFIN POLYMERIZATION PROCESS BASELL POLYOLEFINE GMBH (DE) 2015-07-15 EP disclosed
US-8957159-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-02-17 US disclosed
US-20140066567-A1 Multiple Catalyst System for Olefin Polymerization and Polymers Produced Therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2014-03-06 US disclosed
US-8563647-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2013-10-22 US disclosed
EP-1088836-B1 ETHYLENE/ALPHA-OLEFIN/UNCONJUGATED POLYENE COPOLYMER RUBBER, RUBBER COMPOSITION FOR SEALING, MOLDED RUBBER FOR SEALING, AND PROCESS FOR PRODUCING THE MOLDED RUBBER PART MITSUI CHEMICALS INC (JP) 2012-11-21 EP disclosed
EP-0692505-A2 Process for procucing propylene block copolymers MITSUBISHI CHEMICAL CORPORATION (JP) 1996-01-17 EP disclosed
EP-0691354-A1 Unsaturated copolymer of ethylene and process for preparing the same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1996-01-10 EP disclosed
US-5468781-A Metallocene polymerization catalyst MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1995-11-21 US disclosed
EP-0682042-A1 PROPYLENE ELASTOMER MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-11-15 EP disclosed
US-5346925-A Method for producing α-olefin polymers MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1994-09-13 US disclosed
EP-0611795-A1 Polypropylene resin expanded particles MITSUBISHI CHEMICAL CORPORATION (JP) 1994-08-24 EP disclosed
EP-0598543-A2 Method for producing Alpha-olefin polymers MITSUBISHI CHEMICAL CORPORATION (JP) 1994-05-25 EP disclosed