Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | HTR7 | P34969 | 4/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL672585 | 0.97 | USP30 (0.32) | USP30CHRNB2CHRNA4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL390312 | 0.94 | USP30 (0.33) | USP30CHRNB2CHRNA4HTR1AHTR7 | |
| Fluoride Ion SCHEMBL7636075 | 0.92 | USP30 (0.33) | USP30CHRNB2CHRNA4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6889773 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL7192493 | 0.90 | USP30 (0.32) | USP30CHRNB2CHRNA4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6895031 | 0.86 | EDNRB (0.32) | — | |
| Hydrochloric Acid SCHEMBL6894652 | 0.86 | BRD4 (0.33) | BRD4 | |
| Hydrochloric Acid SCHEMBL6895143 | 0.86 | BRD4 (0.33) | BRD4 | |
| Hydrochloric Acid SCHEMBL6892455 | 0.86 | CYP3A4 (0.35) | HTR1AHTR7DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL6884806 | 0.85 | DRD2 (0.35) | SIGMAR1CYP11B2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620448-B1 | PROCESS FOR THE PRODUCTION OF HALIDE METALLOCENE COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2010-06-16 | — | — | EP | disclosed |
| US-7468451-B2 | Process for the production of halide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| EP-1381618-B1 | PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-20070043228-A1 | Process for the production of halide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2007-02-22 | — | — | US | disclosed |
| US-7115761-B2 | Process for the production of monohalide or dihalide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2006-10-03 | — | — | US | disclosed |
| US-20060025621-A1 | Process for the production of monohalide or dihalide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2006-02-02 | — | — | US | disclosed |
| US-6987196-B2 | Process for the production of monohalide or dihalide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2006-01-17 | — | — | US | disclosed |
| US-6784305-B2 | DERIVATIVES OF ZIRCONOCENE DICHLORIDE IN WHICH THE TWO SUBSTITUTED INDENYL GROUPS ARE JOINED TO ONE ANOTHER VIA A BRIDGE CAN, OWING TO THEIR CONFORMATIONAL RIGIDITY, BE USED AS CATALYSTS FOR THE STEREOSPECIFIC POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2004-08-31 | — | — | US | disclosed |
| US-20040147770-A1 | Process for the production of monohalide or dihalide metallocene compounds | EQUISTAR CHEMICALS, LP | 2004-07-29 | — | — | US | disclosed |
| US-20030199703-A1 | Method for producing alkyl-bridged ligand systems and transition metal compounds | EQUISTAR CHEMICALS, LP | 2003-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043228-A1 | Process for the production of halide metallocene compounds | TPO, SOD1, TXNL1 | USP30 692/4885CHRNB2 4090/4885CHRNA4 4197/4885 |
| US-20030199703-A1 | Method for producing alkyl-bridged ligand systems and transition metal compounds | ABL1, ICMT, ORAI2 | USP30 4487/4885CHRNB2 3083/4885CHRNA4 2408/4885 |
| US-20060025621-A1 | Process for the production of monohalide or dihalide metallocene compounds | SOD1, HAO2, HMOX2 | USP30 754/4885CHRNB2 1741/4885CHRNA4 3289/4885 |
| US-20040147770-A1 | Process for the production of monohalide or dihalide metallocene compounds | SOD1, HAO2, MT-CO1 | USP30 826/4885CHRNB2 2774/4885CHRNA4 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.