Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 7/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903074 | 0.90 | CASR (0.50) | CASRP2RX7OPRL1OPRM1HPGD | |
| SCHEMBL3907315 | 0.83 | GAA (0.43) | CASROPRL1OPRM1 | |
| SCHEMBL3910248 | 0.80 | SLC6A4 (0.49) | CASROPRL1OPRM1HPGD | |
| SCHEMBL3908089 | 0.79 | CASR (0.53) | CASRP2RX7OPRL1NPC1RAB9A | |
| SCHEMBL3905074 | 0.79 | CASR (0.53) | CASRP2RX7OPRL1OPRM1NPC1 | |
| SCHEMBL3908102 | 0.78 | CASR (0.47) | CASROPRL1OPRM1HPGDNPC1 | |
| SCHEMBL3903167 | 0.78 | OPRM1 (0.44) | CASRP2RX7OPRL1OPRM1CRHBP | |
| SCHEMBL3908324 | 0.78 | MEN1 (0.46) | CASROPRM1HPGD | |
| SCHEMBL3905381 | 0.78 | CASR (0.45) | CASRP2RX7OPRL1 | |
| SCHEMBL3906098 | 0.77 | OPRL1 (0.56) | CASROPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |