Sugi Predict

Sugi Predict / Compounds / SCHEMBL390643

SCHEMBL390643

SCHEMBL390643

NS(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.59
▸ SMN1; SMN2 Q16637 4/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ HSD17B10 Q99714 1/20 0.58
▸ CA2 P00918 5/20 0.53
▸ CA12 O43570 4/20 0.53
▸ CA1 P00915 4/20 0.53
▸ CA9 Q16790 4/20 0.53
▸ CA5A P35218 2/20 0.53
▸ CA14 Q9ULX7 2/20 0.53
▸ CA3 P07451 1/20 0.53
▸ CA4 P22748 1/20 0.53
▸ CA6 P23280 1/20 0.53
▸ CA7 P43166 1/20 0.53
▸ CA13 Q8N1Q1 1/20 0.53
▸ CA5B Q9Y2D0 1/20 0.53
▸ VCAM1 P19320 2/20 0.53
▸ RAB9A P51151 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2025933 0.86 HSD17B10 (0.58) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL10453008 0.85 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL10453009 0.85 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL18574585 0.84 CA1 (0.44) ALDH1A1SMN1; SMN2KMT2AMEN1CA2
SCHEMBL29403247 0.84 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL452351 0.84 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL9838827 0.82 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL2483870 0.82 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL390493 0.82 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10
SCHEMBL6110373 0.82 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2KMT2AMEN1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12582660-B2 Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2026-03-24 — — US disclosed
EP-4053108-B1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-03-11 — — EP disclosed
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-02-26 — — US disclosed
US-12503444-B2 Compound containing benzene ring and application thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2025-12-23 — — US disclosed
EP-3790541-B1 N-(3-(AZEPAN-1-YLSULFONYI)-PHENYL)-2-((2-((3-PHENYL)AMINO)-2-OXOETHYL)(METHYL)AMINO)-ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RAS ONCOPROTEIN INHIBITORS FOR THE TREATMENT OF CANCER UNIV LOUISVILLE RES FOUND INC (US) 2024-12-04 — — EP disclosed
CN-114984003-B Aromatic sulfonamide derivatives 拜耳制药股份公司 2024-08-27 — — CN disclosed
CN-115572282-B Pyrazole amide compound containing aromatic heterocyclic structure, and preparation method and application thereof 华东理工大学 2024-07-09 — — CN disclosed
CN-115054600-B Aromatic sulfonamide derivatives 拜耳制药股份公司 2024-06-14 — — CN disclosed
CN-111196804-B TGF-beta R1 inhibitors and uses thereof 南京圣和药业股份有限公司 2023-11-07 — — CN disclosed
CN-114845996-B Benzene ring-containing compound and application thereof 武汉朗来科技发展有限公司 2023-09-12 — — CN disclosed
WO-1997049692-A1 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1997-12-31 — — WO disclosed
WO-1997037646-A1 CATECHOLAMINE SURROGATES USEFUL AS β3 AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 1997-10-16 — — WO disclosed
US-4806640-A Triphendioxazine reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1989-02-21 — — US disclosed
EP-0205080-B1 TRIPHENODIOXAZINE-DISULFIMIDE REACTIVE DYES BAYER AG (DE) 1989-01-18 — — EP disclosed
EP-0205080-A2 Triphenodioxazine-disulfimide reactive dyes BAYER AG (DE) 1986-12-17 — — EP disclosed
EP-0204245-A2 Reactive dyes BAYER AG (DE) 1986-12-10 — — EP disclosed
EP-0087446-B1 METHOD OF FORMING A PHOTOGRAPHIC DYE IMAGE KODAK LIMITED (GB) 1986-07-09 — — EP disclosed
US-4481268-A METALLIZED AZO OR AZO-METHINE DYES EASTMAN KODAK COMPANY (US) 1984-11-06 — — US disclosed
EP-0087446-A1 METHOD OF FORMING A PHOTOGRAPHIC DYE IMAGE. KODAK LTD (GB) 1983-09-07 — — EP disclosed
WO-1983000939-A1 METHOD OF FORMING A PHOTOGRAPHIC DYE IMAGE BAILEY, JOSEPH 1983-03-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12582660-B2 Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof KRAS, NRAS, HRAS ALDH1A1 1982/4885SMN1; SMN2 880/4885KMT2A 484/4885
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF CNR2, RYR2, CNR1 ALDH1A1 756/4885SMN1; SMN2 261/4885KMT2A 4122/4885
US-12503444-B2 Compound containing benzene ring and application thereof P2RX4, P2RX7, P2RX2 ALDH1A1 817/4885SMN1; SMN2 1659/4885KMT2A 4083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.