Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | BID | P55957 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.40 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27915847 | 0.81 | ALDH1A1 (0.59) | MAPTPPARAPPARGBIDMCL1 | |
| SCHEMBL27310479 | 0.78 | ALDH1A1 (0.56) | MAPTPPARAPPARGBIDMCL1 | |
| Methane SCHEMBL28323551 | 0.77 | ALDH1A1 (0.54) | MAPTPPARAPPARGBIDMCL1 | |
| Ethylene SCHEMBL27471464 | 0.76 | ALDH1A1 (0.53) | MAPTPPARAPPARGBIDMCL1 | |
| Ethylene Glycol SCHEMBL27998459 | 0.76 | ALDH1A1 (0.52) | MAPTPPARAPPARGBIDMCL1 | |
| SCHEMBL11634685 | 0.75 | PPARA (0.54) | MAPTPPARAPPARGBIDMCL1 | |
| SCHEMBL28040667 | 0.75 | MAPT (0.44) | MAPTPPARAPPARGTDP1TSHR | |
| SCHEMBL12921072 | 0.75 | HPGD (0.53) | MAPTPPARAPPARGBIDMCL1 | |
| SCHEMBL28456642 | 0.75 | MAPT (0.54) | MAPTTDP1TSHRTP53CYP3A4 | |
| SCHEMBL6125235 | 0.75 | MAPT (0.50) | MAPTTDP1MAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016044-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | The President and Fellows of Harvard College (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007117639-A9 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | HARVARD COLLEGE (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007117639-A2 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |