Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 6/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3917188 | 0.81 | ACMSD (0.40) | ACMSDGRM2CSF1RHDAC3HDAC1 | |
| SCHEMBL3089990 | 0.76 | CSF1R (0.53) | ACMSDPTGS2GRM2CSF1RBTK | |
| SCHEMBL3083131 | 0.75 | CHUK (0.52) | ACMSDGRM2CSF1RIKBKB | |
| SCHEMBL5189366 | 0.74 | BCAT2 (0.49) | ACMSDPTGS2GRM2CSF1RSCN9A | |
| SCHEMBL3083329 | 0.74 | MKNK1 (0.58) | CSF1R | |
| SCHEMBL3076858 | 0.73 | CSF1R (0.48) | ACMSDGRM2CSF1RHDAC3HDAC1 | |
| SCHEMBL3081416 | 0.73 | ACMSD (0.38) | ACMSDGRM2CSF1RHDAC3HDAC1 | |
| SCHEMBL3076846 | 0.72 | PSMB5 (0.46) | ACMSDGRM2CSF1RHDAC3HDAC1 | |
| SCHEMBL3342848 | 0.72 | NPC1 (0.41) | CHEK1IKBKBBTK | |
| SCHEMBL3086556 | 0.72 | CSF1R (0.55) | ACMSDGRM2CSF1RHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016057-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007123516-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |