Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12345855 | 0.85 | SCN9A (0.49) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| SCHEMBL6178932 | 0.85 | SCN9A (0.49) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| SCHEMBL3914974 | 0.80 | KMT2A (0.41) | BRD4RIPK1POLBKMT2A | |
| SCHEMBL4198010 | 0.80 | KMT2A (0.41) | BRD4RIPK1POLBKMT2A | |
| SCHEMBL1394234 | 0.79 | RIPK1 (0.41) | MTNR1AMTNR1BRIPK1POLBKMT2A | |
| SCHEMBL12345856 | 0.78 | EPHX2 (0.59) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| SCHEMBL14386531 | 0.78 | ALOX12 (0.71) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL2236123 | 0.77 | EPHX2 (0.58) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| SCHEMBL12345854 | 0.75 | METAP1 (0.52) | EPHX2ALOX12HDAC2HDAC8HDAC6 | |
| SCHEMBL2234708 | 0.75 | METAP1 (0.52) | EPHX2ALOX12HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029555-A2 | DERIVATIVES OF 2-ALKOXY-3,4,5-TRIHYDROXY-ALKYL AMIDES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING THE SAME | Sanofi-Aventis (FR) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007135295-A2 | DERIVATIVES OF 2-ALKOXY-3,4,5-TRIHYDROXY-ALKYL AMIDES, PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING THE SAME | SANOFI-AVENTIS (FR) | 2007-11-29 | — | — | WO | disclosed |