Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.55 |
| ▸ | REN | P00797 | 14/20 | 0.46 |
| ▸ | CTSD | P07339 | 3/20 | 0.46 |
| ▸ | CTSE | P14091 | 2/20 | 0.46 |
| ▸ | PGC | P20142 | 2/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3913846 | 0.78 | GBA1 (0.49) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL8222697 | 0.78 | GBA1 (0.64) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL8225329 | 0.77 | GBA1 (0.58) | GBA1RENCTSDCTSEPGC | |
| Hydrochloric Acid SCHEMBL4231452 | 0.76 | GBA1 (0.62) | GBA1RENCTSDCTSEPGC | |
| Hydrochloric Acid SCHEMBL3907289 | 0.76 | GBA1 (0.62) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL3914822 | 0.76 | GBA1 (0.47) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL3923532 | 0.76 | GBA1 (0.47) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL11680968 | 0.75 | GBA1 (0.53) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL22279596 | 0.74 | GBA1 (0.55) | GBA1RENCTSDCTSEPGC | |
| SCHEMBL19358440 | 0.74 | GBA1 (0.80) | GBA1RENCTSDCTSEPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029544-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2009-03-04 | — | — | EP | claimed |
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | claimed |