Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDH2 | P40926 | 6/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.55 |
| ▸ | CDK1 | P06493 | 5/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606224 | 0.69 | HRH3 (0.61) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL20100235 | 0.69 | HRH3 (0.61) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL6932101 | 0.69 | HRH3 (0.61) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL20100236 | 0.69 | HRH3 (0.61) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL3157861 | 0.69 | HRH3 (0.61) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL9458309 | 0.69 | ALDH1A1 (0.67) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL16632600 | 0.69 | ALDH1A1 (0.67) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL9458677 | 0.69 | ALDH1A1 (0.67) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL4853372 | 0.69 | ALDH1A1 (0.67) | ALDH1A1NPC1MAPTRAB9ATSHR | |
| SCHEMBL9458671 | 0.69 | ALDH1A1 (0.67) | ALDH1A1NPC1MAPTRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027125-A1 | PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007129119-A1 | PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-11-15 | — | — | WO | disclosed |