Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735675 | 0.87 | TSHR (0.81) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL6738518 | 0.83 | TSHR (0.96) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL3936704 | 0.81 | TSHR (1.00) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL9612077 | 0.81 | TSHR (1.00) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL5127258 | 0.80 | TSHR (0.71) | TSHRHPGDKMT2ARAB9ANPC1 | |
| Hydrazine SCHEMBL28119021 | 0.80 | TSHR (0.89) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL28949192 | 0.79 | HPGD (0.68) | TSHRHPGDKMT2ARAB9AALDH1A1 | |
| SCHEMBL656086 | 0.79 | TSHR (0.69) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL3778246 | 0.79 | LMNA (0.71) | TSHRHPGDKMT2ARAB9ANPC1 | |
| SCHEMBL4608001 | 0.79 | KMT2A (0.85) | TSHRHPGDKMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521473-B2 | Inhibitors of protein tyrosine phosphatase 1B | WYETH (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521473-B2 | Inhibitors of protein tyrosine phosphatase 1B | WYETH (US) | 2009-04-21 | — | — | US | disclosed |
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
| US-20050203087-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203087-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRO, PTPRS, PTPRM | TSHR 1019/4885HPGD 3417/4885KMT2A 2996/4885 |
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | TSHR 682/4885HPGD 3761/4885KMT2A 2570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.