Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3903026 | 0.85 | TAAR1 (0.62) | TAAR1SMN1; SMN2GPR84MPOMEN1 | |
| SCHEMBL4370137 | 0.83 | AURKB (0.76) | TAAR1CDC7PLK4CHEK1DAPK3 | |
| SCHEMBL3906088 | 0.81 | TAAR1 (0.50) | TAAR1SMN1; SMN2GPR84MPOKMT2A | |
| SCHEMBL9056608 | 0.79 | CYP19A1 (0.55) | CDC7PLK4CHEK1DAPK3RPS6KA5 | |
| SCHEMBL9114164 | 0.79 | TAAR1 (0.55) | TAAR1SMN1; SMN2GPR84MPOMEN1 | |
| SCHEMBL19476126 | 0.79 | TAAR1 (0.59) | TAAR1SMN1; SMN2GPR84MPOMEN1 | |
| SCHEMBL5543697 | 0.79 | TAAR1 (0.55) | TAAR1SMN1; SMN2GPR84MPOMEN1 | |
| SCHEMBL2126506 | 0.76 | F2 (0.71) | FLT4ROCK1F2KCNH2GRIN2B | |
| SCHEMBL1568144 | 0.74 | RAB9A (0.64) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9587704 | 0.73 | HRH1 (0.53) | TAAR1SMN1; SMN2MPOALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |