Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.59 |
| ▸ | AXL | P30530 | 5/20 | 0.59 |
| ▸ | MST1R | Q04912 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.59 |
| ▸ | TEK | Q02763 | 3/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | BTK | Q06187 | 2/20 | 0.59 |
| ▸ | STK10 | O94804 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | TIE1 | P35590 | 2/20 | 0.59 |
| ▸ | MERTK | Q12866 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3911282 | 0.91 | AXL (0.59) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL3911444 | 0.85 | MET (0.64) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL3916357 | 0.85 | MET (0.64) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL3911157 | 0.84 | MET (0.51) | METAXLMST1RFLT3FLT4 | |
| SCHEMBL3911419 | 0.82 | MET (0.60) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL371943 | 0.82 | MET (0.63) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL372158 | 0.82 | MET (0.63) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL2923405 | 0.82 | MET (0.63) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL372302 | 0.82 | MET (0.63) | METAXLMST1RFLT3FLT1 | |
| SCHEMBL409723 | 0.82 | MET (0.70) | METAXLMST1RFLT3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | claimed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |