Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.51 |
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MST1R | Q04912 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5056214 | 0.94 | MET (0.52) | METKDR | |
| SCHEMBL3913559 | 0.84 | MET (0.59) | METAXLKDRPDGFRAKIT | |
| SCHEMBL3911282 | 0.82 | AXL (0.59) | METAXLKDRPDGFRAKIT | |
| SCHEMBL29182955 | 0.80 | MET (0.54) | METAXLKDRPDGFRAKIT | |
| SCHEMBL408158 | 0.77 | MET (0.62) | METAXLKDRPDGFRAKIT | |
| SCHEMBL31412944 | 0.77 | MET (0.62) | METAXLKDRPDGFRAKIT | |
| SCHEMBL5186596 | 0.77 | MET (0.53) | METAXLKDRPDGFRA | |
| SCHEMBL12024223 | 0.76 | FGFR2 (0.49) | METAXLKDRPDGFRA | |
| SCHEMBL25188193 | 0.75 | MET (0.52) | METAXLKDRPDGFRAKIT | |
| SCHEMBL29991083 | 0.75 | MET (0.52) | METAXLKDRPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | claimed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |