Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | GFRA3 | O60609 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921730 | 0.93 | CDK2 (0.47) | ERN1LRRK2CDK2CDK9CTSA | |
| SCHEMBL2862184 | 0.86 | GFRA3 (0.51) | CDK2GFRA3RETSLKMGLL | |
| SCHEMBL8993237 | 0.85 | ERN1 (0.58) | ERN1CTSAMGLLMCL1 | |
| SCHEMBL3918169 | 0.83 | CYP11B1 (0.43) | ERN1LRRK2CDK2CDK9CTSA | |
| SCHEMBL2859316 | 0.78 | PDGFRB (0.51) | CDK2GFRA3RETSLKSYK | |
| SCHEMBL8615551 | 0.76 | ERN1 (0.49) | ERN1LRRK2CTSAPRMT5MCL1 | |
| SCHEMBL8614216 | 0.76 | ERN1 (0.49) | ERN1LRRK2CTSAPRMT5 | |
| SCHEMBL21162496 | 0.76 | ERN1 (0.59) | ERN1CTSAMGLLMCL1 | |
| SCHEMBL27756247 | 0.75 | ERN1 (0.51) | ERN1LRRK2CTSAPRMT5 | |
| SCHEMBL3920789 | 0.75 | LRRK2 (0.42) | ERN1LRRK2CDK2CDK9CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |