Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920789 | 0.94 | LRRK2 (0.42) | CYP11B1CYP11B2ERN1LRRK2FEN1 | |
| SCHEMBL3988518 | 0.87 | CYP11B1 (0.47) | CYP11B1CYP11B2FEN1CDK2KDM4E | |
| SCHEMBL3913833 | 0.83 | ERN1 (0.46) | ERN1LRRK2MCL1CCNT1CCNA2 | |
| SCHEMBL8993237 | 0.80 | ERN1 (0.58) | CYP11B1CYP11B2ERN1MCL1CTSA | |
| SCHEMBL8616633 | 0.76 | MRGPRX4 (0.48) | ERN1FEN1CTSAPRMT5 | |
| SCHEMBL387683 | 0.76 | ERN1 (0.44) | ERN1LRRK2MCL1FEN1CTSA | |
| SCHEMBL3921730 | 0.75 | CDK2 (0.47) | ERN1LRRK2CCNT1CCNA2CDK2 | |
| SCHEMBL7793991 | 0.72 | XDH (0.53) | ERN1FEN1CTSAPRMT5 | |
| SCHEMBL387208 | 0.72 | RORC (0.46) | ERN1FEN1 | |
| SCHEMBL8613081 | 0.72 | ALOX5AP (0.47) | ERN1FEN1CTSAPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |