SCHEMBL3914130

SCHEMBL3914130

Cc1cccc(C(N)=O)c1CCO

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD38 P28907 3/20 0.44
CYP3A4 P08684 2/20 0.44
KCNH2 Q12809 1/20 0.44
SIRT1 Q96EB6 1/20 0.42
PARP1 P09874 5/20 0.40
ALDH1A1 P00352 3/20 0.40
HPGD P15428 3/20 0.40
LMNA P02545 1/20 0.40
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MYC P01106 1/20 0.40
KDM4E B2RXH2 2/20 0.39
HSD17B10 Q99714 2/20 0.39
BCAT2 O15382 1/20 0.39
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
CXCR5 P32302 1/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
PARP2 Q9UGN5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27800518 0.87 SIRT1 (0.47) SIRT1PARP1ALDH1A1HPGDKDM4E
SCHEMBL4235369 0.86 CXCR5 (0.49) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL30585075 0.85 CD38 (0.46) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL27556126 0.84 CYP3A4 (0.46) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL28857190 0.84 CD38 (0.43) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL28204636 0.83 CD38 (0.42) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL6013405 0.83 CXCR5 (0.51) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL1660584 0.81 PARP1 (0.46) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL8706621 0.81 PARP1 (0.46) CD38CYP3A4KCNH2PARP1ALDH1A1
SCHEMBL6013408 0.81 LMNA (0.51) CD38CYP3A4KCNH2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940782-B1 N-PHENYL PHENYLACETAMIDE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-03-11 EP disclosed