Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12622263 | 0.81 | KDM4E (0.42) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL12673039 | 0.80 | KMT2A (0.38) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL27623455 | 0.78 | KDM4E (0.45) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL6990825 | 0.77 | KMT2A (0.34) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL1030459 | 0.76 | KDM4E (0.48) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL6604064 | 0.75 | KDM4E (0.42) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL1899099 | 0.75 | KMT2A (0.49) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL30880791 | 0.75 | ADORA3 (0.50) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL7529038 | 0.75 | KMT2A (0.45) | KMT2AKDM4ENAPRTHCAR2TSHR | |
| SCHEMBL306075 | 0.75 | ADORA3 (0.50) | KMT2AKDM4ENAPRTHCAR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105916858-B | Condensed imidazole radical derivative, its preparation and the purposes as drug | 埃斯特韦制药股份公司 | 2018-09-14 | — | — | CN | claimed |
| CN-105916858-A | Fused imidazolyl derivatives, their preparation and use as medicaments | 埃斯特韦博士实验室股份公司 | 2016-08-31 | — | — | CN | claimed |
| CN-114621243-B | Sulfonamide derivative and application thereof | 上海拓界生物医药科技有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117396485-A | PARP7 inhibitors | 轩竹生物科技股份有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-116783199-A | Pyrazolo [1,5-A ] pyrazine derivatives as BTK inhibitors | 渤健马萨诸塞州股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| US-20230082167-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2023-03-16 | — | — | US | disclosed |
| WO-2022247839-A1 | PARP7 INHIBITOR | 山东轩竹医药科技有限公司 | 2022-12-01 | — | — | WO | disclosed |
| CN-114621243-A | Sulfonamide derivative and application thereof | 上海拓界生物医药科技有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-105916858-B | Condensed imidazole radical derivative, its preparation and the purposes as drug | 埃斯特韦制药股份公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-107207504-A | Phthalazinone derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105073742-B | FLAP conditioning agents | 詹森药业有限公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-1780612-B | Treatment of incontinence with 5HT2C agonists. | PFIZER | 2010-12-01 | — | — | CN | disclosed |
| CN-101501006-A | Pyridone and pyridazinone derivatives as poly (ADP-ribose) polymerase (PARP) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-08-05 | — | — | CN | disclosed |
| CN-101417999-A | Piperazines derivates, preparation method thereof and application thereof in medicine | SHANGHAI HENGRUI PHARM CO LTD (CN) | 2009-04-29 | — | — | CN | disclosed |
| EP-2032140-A1 | PYRROLO[1,2-A]PYRAZIN-1(2H)-ONE AND PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP) | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138355-A1 | PYRROLO[1,2-A]PYRAZIN-1(2H)-ONE AND PYRROLO[1,2-D][1,2,4]TRIAZIN-1(2H)-ONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE(PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-12-06 | — | — | WO | disclosed |
| CN-1867554-A | Piperazine with ortho-substituted phenyl and its use as GLYT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2006-11-22 | — | — | CN | disclosed |
| CN-1780612-A | Treatment of incontinence with 5HT2C agonists. | PFIZER (US) | 2006-05-31 | — | — | CN | disclosed |
| EP-1025102-A1 | BICYCLIC KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020624-A1 | BICYCLIC KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 1999-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230082167-A1 | NOVEL TRICYCLIC COMPOUNDS | CYP11B2, CYP11B1, ABCB1 | KMT2A 3801/4885KDM4E 4050/4885NAPRT 1750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.