Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | GRK2 | P25098 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19636581 | 0.86 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL13310570 | 0.86 | ALDH1A1 (0.78) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL12793674 | 0.86 | ALDH1A1 (0.78) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL29259796 | 0.85 | ALDH1A1 (0.86) | ALDH1A1SMN1; SMN2EGFRERBB2PKM | |
| SCHEMBL1893565 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL4915517 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL6272107 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL13419650 | 0.85 | ALDH1A1 (0.76) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL120702 | 0.84 | ALDH1A1 (1.00) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL3659182 | 0.84 | ALDH1A1 (0.88) | ALDH1A1TSHRSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |