Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.55 |
| ▸ | AXL | P30530 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3913675 | 0.82 | MET (0.55) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL3913677 | 0.77 | MET (0.65) | METAXL | |
| SCHEMBL5824355 | 0.75 | MET (0.70) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL3921647 | 0.74 | AXL (0.62) | METPDGFRAAXLKDRKIT | |
| SCHEMBL31412937 | 0.72 | MET (0.60) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL31412928 | 0.72 | MET (0.75) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL2860965 | 0.72 | MET (0.63) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL12635551 | 0.72 | PDGFRA (0.78) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL4401175 | 0.72 | MET (0.76) | METPDGFRAAXLKDRMST1R | |
| SCHEMBL3794835 | 0.72 | MET (0.59) | METPDGFRAAXLKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |