SCHEMBL3914969

SCHEMBL3914969

O=C(O)c1ccc2c(c1)C=CC=CN2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.42
CA12 O43570 3/20 0.42
CA2 P00918 3/20 0.42
CA4 P22748 3/20 0.42
CA7 P43166 3/20 0.42
CA9 Q16790 3/20 0.42
MAPT P10636 2/20 0.42
CA1 P00915 2/20 0.42
CA6 P23280 2/20 0.42
CA14 Q9ULX7 2/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
PTGS2 P35354 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TSHR P16473 2/20 0.38
TP53 P04637 1/20 0.38
KDM5A P29375 1/20 0.38
ALDH1A1 P00352 3/20 0.36
HTT P42858 2/20 0.36
SIRT2 Q8IXJ6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1007936 0.84 LCK (0.37) KDM4EMAPTPOLBL3MBTL1TSHR
SCHEMBL4671199 0.80 CA1 (0.49) KDM4ECA12CA2CA7CA9
SCHEMBL18522671 0.75 TSHR (0.46) KDM4ECA12CA2CA4CA7
SCHEMBL1227400 0.75 KDM4E (0.36) KDM4ECA12CA2CA4CA7
Oxalic Acid SCHEMBL8507926 0.73 MAPT (0.39) KDM4EMAPTPOLBGAAL3MBTL1
SCHEMBL12482950 0.70 KDM4E (0.45) KDM4ECA12CA2CA4CA7
Succinic Acid SCHEMBL5729591 0.69 NR4A2 (0.43) MAPTGAAL3MBTL1TSHRALDH1A1
Fumaric Acid SCHEMBL4504232 0.69 ALDH1A1 (0.37) KDM4EMAPTGAAALDH1A1HTT
SCHEMBL3833920 0.69 KDM4E (0.37) KDM4ECA12CA2CA4CA7
Maleic Acid SCHEMBL4504225 0.69 ALDH1A1 (0.37) KDM4EMAPTGAAALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052492-A1 FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 Cancer Research Technology Limited (GB) 2016-08-10 EP disclosed
WO-2015049535-A1 FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2015-04-09 WO disclosed
EP-2027125-A1 PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2009-02-25 EP disclosed
EP-1951676-A2 LXR MODULATORS Brystol-Myers Squibb Company (US) 2008-08-06 EP disclosed
WO-2007129119-A1 PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-11-15 WO disclosed
WO-2007050425-A2 LXR MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-03 WO disclosed
EP-1751163-A2 COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF GLAXO GROUP LIMITED (GB) 2007-02-14 EP disclosed
WO-2005118549-A2 COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF GLAXO GROUP LIMITED (GB) 2005-12-15 WO disclosed
WO-2000073313-A1 NEW TRICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE ASTRAZENECA AB (SE) 2000-12-07 WO disclosed