Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.63 |
| ▸ | MST1R | Q04912 | 4/20 | 0.63 |
| ▸ | KDR | P35968 | 4/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.63 |
| ▸ | FLT4 | P35916 | 3/20 | 0.63 |
| ▸ | TEK | Q02763 | 3/20 | 0.63 |
| ▸ | BTK | Q06187 | 3/20 | 0.63 |
| ▸ | HGF | P14210 | 2/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 2/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.63 |
| ▸ | AXL | P30530 | 3/20 | 0.63 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | CSF1R | P07333 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | STK25 | O00506 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921784 | 0.94 | MET (0.65) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL3914211 | 0.85 | AXL (0.64) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL3921528 | 0.82 | MET (0.70) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL3912718 | 0.81 | AXL (0.65) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL2863205 | 0.80 | MET (0.78) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL3915218 | 0.80 | MET (0.75) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL1555923 | 0.79 | AXL (0.78) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL2861723 | 0.79 | MET (0.78) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL13896124 | 0.79 | AXL (0.82) | METMST1RKDREGFRRPS6KB1 | |
| SCHEMBL2868744 | 0.78 | MET (0.77) | METMST1RKDREGFRRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032538-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146824-A2 | QUINOLINE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-12-21 | — | — | WO | disclosed |