Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.82 |
| ▸ | FLT3 | P36888 | 4/20 | 0.74 |
| ▸ | MET | P08581 | 14/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.66 |
| ▸ | MST1R | Q04912 | 3/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.66 |
| ▸ | FLT4 | P35916 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | TEK | Q02763 | 2/20 | 0.66 |
| ▸ | BTK | Q06187 | 2/20 | 0.66 |
| ▸ | PLK4 | O00444 | 1/20 | 0.66 |
| ▸ | STK25 | O00506 | 1/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | CHUK | O15111 | 1/20 | 0.66 |
| ▸ | MUSK | O15146 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14289180 | 0.90 | AXL (1.00) | AXLFLT3METEGFRMST1R | |
| SCHEMBL4059389 | 0.90 | AXL (0.81) | AXLFLT3METEGFRMST1R | |
| SCHEMBL166239 | 0.90 | AXL (1.00) | AXLFLT3METEGFRMST1R | |
| SCHEMBL30000966 | 0.90 | AXL (1.00) | AXLFLT3METEGFRMST1R | |
| SCHEMBL16070034 | 0.89 | AXL (0.66) | AXLFLT3METEGFRMST1R | |
| SCHEMBL16069960 | 0.89 | AXL (0.79) | AXLFLT3METEGFRMST1R | |
| SCHEMBL14320219 | 0.89 | AXL (0.79) | AXLFLT3METEGFRMST1R | |
| SCHEMBL15277712 | 0.89 | AXL (0.79) | AXLFLT3METEGFRMST1R | |
| SCHEMBL19372835 | 0.88 | AXL (0.64) | AXLFLT3METEGFRMST1R | |
| SCHEMBL6431273 | 0.87 | AXL (0.73) | AXLFLT3METEGFRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017029362-A1 | ASYMMETRIC BISAMIDATION OF MALONIC ESTER DERIVATIVES | SANDOZ AG (CH) | 2017-02-23 | — | — | WO | disclosed |
| US-20140186407-A9 | C-Met Modulator Pharmaceutical Compositions | EXELIXIS INC. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140186407-A9 | C-Met Modulator Pharmaceutical Compositions | EXELIXIS INC. (US) | 2014-07-03 | — | — | US | disclosed |
| EP-2392564-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| US-20130197230-A1 | METHODS OF PREPARING QUINOLINE DERIVATIVES | EXELIXIS, INC. | 2013-08-01 | — | — | US | disclosed |
| WO-2013059788-A1 | PROCESS FOR PREPARING QUINOLINE DERIVATIVES | EXELIXIS, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20130030172-A1 | Methods of Preparing Quinoline Derivatives | EXELIXIS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8314232-B2 | Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide | GLAXOSMITHKLINE LLC (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314232-B2 | Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide | GLAXOSMITHKLINE LLC (US) | 2012-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130197230-A1 | METHODS OF PREPARING QUINOLINE DERIVATIVES | F12, RECQL, H1-2 | AXL 3708/4885FLT3 210/4885MET 3697/4885 |
| US-20130030172-A1 | Methods of Preparing Quinoline Derivatives | F12, RECQL, H1-2 | AXL 3482/4885FLT3 185/4885MET 3338/4885 |
| US-20140186407-A9 | C-Met Modulator Pharmaceutical Compositions | MET, HGFAC, HGF | AXL 1864/4885FLT3 218/4885MET 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.