Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997899 | 0.83 | KDM4E (0.52) | CYP2D6TSHRPDCD1CD274KDM4E | |
| SCHEMBL2075627 | 0.82 | NR1H2 (0.59) | TSHRKDM4EALDH1A1POLBHTT | |
| SCHEMBL22172136 | 0.82 | GAA (0.56) | CYP2D6TSHRKDM4EALDH1A1HTT | |
| SCHEMBL30309437 | 0.82 | GAA (0.56) | CYP2D6TSHRKDM4EALDH1A1HTT | |
| SCHEMBL2205074 | 0.82 | TSHR (0.59) | TSHRKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL3916828 | 0.81 | ALDH1A1 (0.51) | PDCD1CD274KDM4EALDH1A1POLB | |
| SCHEMBL3179790 | 0.80 | TSHR (0.59) | TSHRKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL13861948 | 0.78 | SMN1; SMN2 (0.48) | KDM4EALDH1A1HTTALOX15MAPK1 | |
| SCHEMBL3919971 | 0.78 | NR1H2 (0.70) | CYP2D6KDM4EALDH1A1POLBHTT | |
| SCHEMBL4263324 | 0.78 | HTT (0.54) | TSHRKDM4EALDH1A1HTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |