Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841405 | 0.85 | ALDH1A1 (0.51) | KDM4EALDH1A1POLBCYP2D6MEN1 | |
| SCHEMBL16380640 | 0.85 | MAPK1 (0.51) | KDM4EALDH1A1POLBCYP2D6MEN1 | |
| SCHEMBL6947771 | 0.85 | L3MBTL1 (0.59) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL4271324 | 0.84 | L3MBTL1 (0.61) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL3992921 | 0.83 | IP6K1 (0.52) | KDM4EALDH1A1ALOX15HTTOPRM1 | |
| SCHEMBL3915944 | 0.83 | CYP2D6 (0.54) | KDM4EALDH1A1POLBALOX15HTT | |
| SCHEMBL4263319 | 0.81 | CYP2D6 (0.52) | KDM4EALDH1A1HTTCYP2D6MEN1 | |
| SCHEMBL3919981 | 0.80 | NPSR1 (0.62) | KDM4EALDH1A1ALOX15HTTCYP2D6 | |
| SCHEMBL2906362 | 0.77 | KDM4E (0.60) | KDM4EALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL2624464 | 0.73 | L3MBTL1 (0.76) | KDM4EALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |