Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916295 | 0.94 | KCNA5 (0.46) | KCNA5KCNH2DRD2DRD4DRD3 | |
| SCHEMBL3916710 | 0.92 | KCNA5 (0.43) | KCNA5KCNH2DRD2SIGMAR1 | |
| SCHEMBL3916281 | 0.86 | SIGMAR1 (0.48) | KCNA5SIGMAR1 | |
| SCHEMBL3925802 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2SIGMAR1 | |
| SCHEMBL4099571 | 0.84 | NPC1 (0.40) | KCNA5DRD2SIGMAR1 | |
| SCHEMBL3916070 | 0.83 | KCNA5 (0.44) | KCNA5KCNH2 | |
| SCHEMBL3925223 | 0.81 | KCNA5 (0.49) | KCNA5KCNH2NAAA | |
| SCHEMBL3917852 | 0.81 | KCNA5 (0.57) | KCNA5KCNH2SIGMAR1 | |
| SCHEMBL3918236 | 0.78 | KCNA5 (0.42) | KCNA5KCNH2DRD2NAAA | |
| SCHEMBL3915740 | 0.78 | KCNA5 (0.44) | KCNA5KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |