Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090604 | 1.00 | MKNK1 (0.36) | MKNK1NAMPTROCK1PTGDR2ALDH1A1 | |
| SCHEMBL391727 | 1.00 | MKNK1 (0.36) | MKNK1NAMPTROCK1PTGDR2ALDH1A1 | |
| SCHEMBL392229 | 0.90 | GPR119 (0.37) | MKNK1NAMPTALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL387107 | 0.87 | KCNH2 (0.43) | CYP2D6CYP2C9GRIN2BCYP3A4KCNH2 | |
| SCHEMBL392226 | 0.85 | GPR119 (0.39) | MKNK1NAMPTALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL388621 | 0.84 | GPR119 (0.40) | CYP2D6CYP2C9GRIN2BCYP3A4KCNH2 | |
| SCHEMBL389694 | 0.84 | TPSAB1 (0.38) | MKNK1GRIN2BGPR119 | |
| SCHEMBL390684 | 0.84 | PTGDR2 (0.34) | PTGDR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL387161 | 0.84 | PTGDR2 (0.34) | PTGDR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL392337 | 0.83 | KCNH2 (0.38) | MKNK1NAMPTCYP2D6CYP2C9GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101626-B2 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | ARENA PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |