Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919974 | 0.88 | ABL1 (0.63) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2347964 | 0.87 | ABL1 (0.65) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2352219 | 0.86 | ABL1 (0.64) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3994946 | 0.85 | ABL1 (0.52) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3994955 | 0.85 | ABL1 (0.52) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL14344806 | 0.85 | ABL1 (0.62) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3926179 | 0.84 | LCK (0.54) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL12459047 | 0.84 | ALDH1A1 (0.65) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2346102 | 0.84 | MAPK14 (0.65) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3915262 | 0.83 | ABL1 (0.59) | ABL1MAPK14LCKCSF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |