Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | CSF1R | P07333 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352219 | 0.99 | ABL1 (0.64) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2346102 | 0.96 | MAPK14 (0.65) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL14344806 | 0.92 | ABL1 (0.62) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL12459047 | 0.91 | ALDH1A1 (0.65) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3919974 | 0.90 | ABL1 (0.63) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2346300 | 0.89 | MAPK14 (0.61) | ABL1MAPK14NPC1ALDH1A1RAB9A | |
| SCHEMBL3917456 | 0.87 | ABL1 (0.59) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL3915262 | 0.86 | ABL1 (0.59) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2346742 | 0.86 | ABL1 (0.59) | ABL1MAPK14LCKCSF1REGFR | |
| SCHEMBL2349949 | 0.84 | MAPK14 (0.57) | ABL1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |