Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405966 | 0.87 | OPRL1 (0.68) | OPRL1OPRM1OPRK1ENPP2CACNA1G | |
| SCHEMBL3633938 | 0.81 | OPRL1 (0.61) | OPRL1OPRM1OPRK1ENPP2KDM4E | |
| SCHEMBL4678737 | 0.80 | OPRL1 (0.63) | OPRL1OPRM1OPRK1ENPP2CACNA1G | |
| SCHEMBL4379955 | 0.75 | CNR2 (0.54) | — | |
| SCHEMBL4379950 | 0.75 | CNR2 (0.54) | — | |
| SCHEMBL4918244 | 0.74 | OPRL1 (0.75) | OPRL1OPRM1OPRK1ENPP2CACNA1G | |
| SCHEMBL4919034 | 0.73 | OPRL1 (1.00) | OPRL1OPRM1OPRK1CACNA1GCACNA1H | |
| Trifluoroacetic Acid SCHEMBL6245311 | 0.73 | CRHR1 (0.46) | OPRL1OPRM1OPRK1ENPP2CACNA1G | |
| SCHEMBL4909901 | 0.73 | OPRL1 (0.77) | OPRL1OPRM1OPRK1ENPP2CACNA1G | |
| SCHEMBL4918313 | 0.72 | OPRL1 (0.75) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114897-A2 | BENZIMIDAZOLONE DERIVATIVES | Pfizer Products Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008032164-A2 | BENZIMIDAZOLONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-03-20 | — | — | WO | disclosed |