SCHEMBL3918436

SCHEMBL3918436

c1ccc2c(NCc3ccncc3)nncc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
KDM4E B2RXH2 2/20 0.53
TP53 P04637 2/20 0.53
CYP3A4 P08684 2/20 0.53
GOT1 P17174 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
PTGS1 P23219 2/20 0.53
MPO P05164 2/20 0.53
ALDH1A1 P00352 2/20 0.53
LMNA P02545 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
PKM P14618 1/20 0.53
MAOA P21397 1/20 0.53
THPO P40225 1/20 0.53
AOX1 Q06278 1/20 0.53
ACOX1 Q15067 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29370429 0.89 KDM4E (0.57) POLBNPC1RAB9AKDM4ETP53
SCHEMBL29372940 0.81 APP (0.57) POLBNPC1RAB9AKDM4ETP53
SCHEMBL3758755 0.81 APP (0.57) POLBNPC1RAB9AKDM4ETP53
SCHEMBL30913256 0.75 KDM4E (0.48) POLBKDM4EALDH1A1LMNAKDR
SCHEMBL3753974 0.75 APP (0.60) NPC1RAB9ATP53SMN1; SMN2MPO
SCHEMBL871138 0.73 CYP19A1 (0.53) NPC1RAB9AKDM4ETP53CYP3A4
SCHEMBL29481851 0.73 CYP19A1 (0.53) NPC1RAB9AKDM4ETP53CYP3A4
SCHEMBL12199237 0.73 MPO (0.57) POLBNPC1RAB9AKDM4ETP53
SCHEMBL28900093 0.73 NPC1 (0.71) NPC1RAB9AKDM4ETP53CYP3A4
SCHEMBL13286756 0.73 NPC1 (0.71) NPC1RAB9AKDM4ETP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4161522-A1 PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS Merck Sharp & Dohme LLC (US) 2023-04-12 EP disclosed
EP-2029551-A2 PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) 2009-03-04 EP disclosed
WO-2008041037-A1 FUSED INDOLES AND INDAZOLES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2008-04-10 WO disclosed
WO-2007138351-A2 PYRIDINONE AND PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) 2007-12-06 WO disclosed