Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925894 | 0.85 | KCNA5 (0.46) | KCNA5KCNH2LMNASMN1; SMN2NPSR1 | |
| SCHEMBL3925321 | 0.79 | ALDH1A1 (0.42) | KCNH2LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2882422 | 0.74 | KCNA5 (0.51) | KCNA5KCNH2FAAHHCRTR1HCRTR2 | |
| SCHEMBL2885223 | 0.74 | KCNA5 (0.62) | KCNA5KCNH2FAAH | |
| SCHEMBL2885524 | 0.70 | KCNA5 (0.63) | KCNA5KCNH2LMNAKDM4EALDH1A1 | |
| SCHEMBL3918641 | 0.66 | KCNA5 (0.45) | KCNA5PDE10ALMNAFAAHPDGFRB | |
| SCHEMBL2879831 | 0.66 | KCNA5 (0.64) | KCNA5KCNH2 | |
| SCHEMBL2887826 | 0.63 | KCNA5 (0.66) | KCNA5KCNH2 | |
| SCHEMBL3717579 | 0.62 | KCNA5 (0.44) | KCNA5LMNAFAAHHCRTR1HCRTR2 | |
| SCHEMBL2879357 | 0.61 | KCNA5 (0.65) | KCNA5KCNH2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |